Learn More. Excite. Must be 21+. These casinos and gaming sites are owned by 14 New Mexico. Sunday - Thursday: 8 AM - 2 AM | Friday & Saturday: Join the fun at Santa Ana Star Casino Hotel, the best casino in New Mexico! Located just north of Albuquerque, NM, we offer Gaming, Bowling, Golf, Dining. Swirls of Cash. . 1. Win. Our New Mexico casino is open 24/7 daily. No Smoking Facility. Upcoming Events. Read More! Sky City's Main Casino and the Travel Center's Slot Area is open 24 hours daily. New Mexico has 23 Indian casinos and 4 Indian gaming travel centers located across 10 counties. A warm and friendly environment with slot machines at the Main Casino. Sky City Casino is open 24 hours daily. Saturdays in. #2 Best Value of 24 Mexico. Unwind. Indulge. Experience Vegas at Albuquerque's Sandia Casino! Test your luck at our slots or play poker, roulette & more! High limit & VIP lounge available. Colorful bingo cards and round bingo balls w/numbers. With three live entertainment venues, you'll find something around every corner. DISCOVER NORTHERN NEW MEXICO AT ITS BEST! The casino is open every day. It's a warm, friendly environment with slot machines. The Travel center includes a casino area with 45 slot machines. at Isleta Resort & Casino. Seadust Cancun Family Resort · 6, reviews. #1 Best Value of 24 Mexico Casino Hotels ; 2. Open 24 hours, 7 days a week! What's happening. The Pyramid Cancun · 4, reviews.